SOME OF OUR CURRENT TARGETS( OF ABOUT 25)
CDK2 ( CYLIN-DEPENDENT KINEASE 2
THIS IS A CRITICAL CELL CYCLE REGULATOR.
BECAUSE IT IS HYPERACTIVATED IN MANY CANCERS, IT IS A MAJOR TARGET FOR THERAPEUTIC INHIBITORS.
ACETYLCHOLINESTERASE
AChE IS A LIGHTIJG FAST ENZYME THAT TERMINATES NERVE SIGNALS BY BREAKING DOWN THE NEUROTRANSMITTER ACETYLCHOLINE INTO ACETIC ACID AND CHOLINE.
DNA GYRASE
WHY ITS VITAL: WITHOUT GYRASE, THE DNA WOULD BEXOME SO TIGHTLY KNOTTED( POSITIVE SUPERCOILING) THAT THE CELL COULD NOT REPLICATE ITS GENOME OR TRANSCRIBE GENES, LEADING TO CELL DEATH!
SARS-COV-2 MAIN PROTEASE
ACTS AS THE MOLECULAR " SCISSORS" OF THE VIRUS!!! Mpro CUTS THESE LONG CHAINS AT SPECEFIC LOCATIONS TO RELEASE INDIVIDUAL, FUNCTIONAL PROTEINS THAT THE VIRUS NEEDS TO REPLICATE.
NEURAMINIDASE
CRITICAL SURFACE PROTEIN FOUND ON THE INFLUENZA VIRUS. NEURAMINIDASE ALLOWS NEW VIRUSES TO BREAK FREE AND INFECT NEIGHBORING CELLS. IT CAUSES THE RAPID SPREAD OF THE FLU THROUGHOUT THE REPSIRATORY SYSTEM!!!
TNF-a
IS A PROTEIN IN OUR IMMUNE SYSTEM .IT ACTS AS AN EMERGENCY ALARN THAT TRIGGERS INFLAMMATION TO HELP FIGHT INFECTIONS. HOWEVER, IF IT STAYS " ON" TOO LONG , IT CAUSES AUTOIMMUNE DISEASES.